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CRBS-MI4 Blue-Sky

2026 CRBS-MI4 Blue-Sky Seed Funding

In March 2026, Centre de recherche en biologie structurale and the 91Ë¿¹ÏÊÓÆµ Interdisciplinary Initiative in Infection and Immunity (MI4) held a collaborative seed funding competition aiming to generate preliminary dataÌýand provide evidence for collaboration across disciplines that will enable the team to seek additional funding from other agencies. The winners received a total of $40,000 for a project implementation period of up to 12 months.

Join us in congratulating the following winners:

Project Title °ä´Ç-±Ê°ù¾±²Ô³¦¾±±è²¹±ôÌý±õ²Ô±¹±ð²õ³Ù¾±²µ²¹³Ù´Ç°ù²õ

Molecular basis of Type IV pili-mediated Pseudomonas aeruginosa – host interactions

Lay Summary

Pseudomonas aeruginosa is a bacterium that causes difficult‑to‑treat infections, especially in people with cystic fibrosis or weakened immune systems. It uses small, hair‑like structures to attach to human cells, resist immune clearance, and persist in the body.

This project studies a key protein at the tip of these structures, called PilY1, which helps the bacteria interact with human tissues. By combining high‑resolution imaging with infection biology, the team will examine how PilY1 works and how small changes in this protein—commonly found in clinical infections—affect bacterial behavior and immune responses.

Understanding how this protein functions could help guide new approaches to block bacterial attachment and improve treatment of persistent infections.

Dao Nguyen

Shuaiqi Guo

Ìý


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