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Shafaat A Rabbani

Title: 
Professor, Division of Endocrinology and Metabolism
Shafaat A Rabbani
Contact Information
Email address: 
shafaat.rabbani [at] mcgill.ca
Location: 
MUHC, Royal Victoria Hospital
Division: 
Endocrinology and Metabolism
Biography: 

Dr. Shafaat Rabbani is a Professor of Medicine at 91Ë¿¹ÏÊÓÆµ. Dr. Rabbani received his medical education at King Edward Medical College Lahore Pakistan. His research led to the characterization of Parathyroid Hormone Related Peptide as the main pathogenetic factor responsible of hypercalcemia of malignancy. He developed several syngeneic and xenograft models of breast and prostate cancer which mimicked the ability of these malignancies to metastasize to the skeleton. Pioneering work carried out in his laboratory led to identification Urokinase as a mitogen for cells of the osteoblast phenotype and a key protease involved in tumor invasion, growth, and metastasis. His group was the first to demonstrate the role of DNA methylation as a key molecular mechanism regulating urokinase gene transcription. Dr. Rabbani serves as a reviewer for several high impact journals and on several study sections in Canada and United States. Dr. Rabbani has issued and filed patents in his area of expertise which has continued to be the role of growth factors and proteases in skeletal metastasis. Over the years he has served as a consultant and member if the scientific advisory board of a number biotechnology and pharmaceutical companies in Canada and United States.

Selected publications: 
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