91丝瓜视频

Cardiac Contraction and Sudden Cardiac Death:听 The Role of Troponin

Speaker:
Professor Glen Tibbits
Canada Research Chair in Cardiac Molecular Physiology
Simon Fraser University

Date: Friday, March 30, 2012

Abstract

Troponin which is located on the thin filament of the cardiac contractile apparatus is a critical initiator of the contractile process.听 This protein is made up of three critical components: troponin C (cTnC), troponin I (cTnI) and troponin T (cTnT) which act in a concerted manner to activate cardiac contraction in response to its physiological trigger rising cytosolic Ca2+ levels.听 These proteins are relatively highly conserved in nature over a span of 400 million years from fish to humans.听 However mutations in troponin proteins can be associated with the disease hypertrophic cardiomyopathy which is the leading cause of sudden cardiac death in young athletes.听 The talk will explore the evolution of troponin as well describe its potential role in sudden cardiac death.

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