/tropmed/fr/aggregator Centre J.D. MacLean pour la médecine tropicale et géographique - flux agrégés fr https://pubmed.ncbi.nlm.nih.gov/41339150/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251205011730&v=2.18.0.post22+67771e2 Loiasis remains one of the least prioritised filarial infections, yet its neglect undermines onchocerciasis elimination and limits progress toward global NTD goals. Recognising Loa loa as a neglected tropical disease would unlock resources, promote safe mass drug administration, and accelerate the World Health Organization's 2030 targets. Wed, 03 Dec 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41328670/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251203000810&v=2.18.0.post22+67771e2 INTRODUCTION: For more than 15 years, artemisinin-based combination therapy (ACT) and atovaquone-proguanil have been recommended as treatment of Plasmodium falciparum malaria in most nonendemic countries. However, new challenges have emerged that complicate the management of travelers with malaria, including the occurrence of artemisinin-related hemolysis and the increasing numbers of treatment failure possibly related to drug resistance. Tue, 02 Dec 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41323793/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251202002514&v=2.18.0.post22+67771e2 Salmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential bacterial genes, have demonstrated potential as antibacterial agents by effectively inhibiting the growth of various pathogens. Peptidoglycan (PG) has historically been one of the central targets for antibiotics in the ongoing battle against... Mon, 01 Dec 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41320122/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251201004152&v=2.18.0.post22+67771e2 Atopic dermatitis (AD) in infants is associated with increased risk of developing other allergic diseases, including asthma. This progression is known as atopic march (AM). We established a murine AM model by first inducing AD-like skin inflammation to house dust mite (HDM) allergen. Mice were subsequently challenged with HDM delivered to the lung. Our data show that epicutaneous sensitization with HDM increased serum IgE, ear thickness, and immune cell infiltration into the skin, accompanied by... Sun, 30 Nov 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41319301/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251201004152&v=2.18.0.post22+67771e2 Rift Valley fever virus (RVFV) is a mosquito-borne phlebovirus that causes severe febrile and hemorrhagic illness in humans. In September 2025, an outbreak in northern Senegal led to 119 confirmed infections and 15 deaths as of October 7, 2025. We performed rapid genomic sequencing to characterize the virus responsible for this epidemic. RNA from RT-qPCR-confirmed samples was sequenced using the Twist Comprehensive Viral Research Panel on an Illumina iSeq 100 platform. Consensus genomes were... Sun, 30 Nov 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41290700/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251126003419&v=2.18.0.post22+67771e2 Genome three-dimensional organization is essential for eukaryotic gene expression. The chromosomes of the pathogen Trypanosoma brucei contain hundreds of silent variant surface glycoprotein (VSG) genes in subtelomeric regions. T. brucei transcribes a single VSG gene and periodically changes the VSG expressed, altering its surface coat to escape host antibodies by antigenic variation. We show that T. brucei core and subtelomeric chromosome compartments are separated by distinct boundaries and... Tue, 25 Nov 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41224774/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251114031338&v=2.18.0.post22+67771e2 Trypanosoma cruzi possesses hundreds of genes associated with pathogenesis. The extent and organization of this diverse gene repertoire, expression, and role in infection remain unclear. Using accurate long-read sequencing and chromatin conformation capture, we assembled T. cruzi Sylvio X10 strain chromosomes from telomere-to-telomere. The genome provides accurate organization of multigene family genes, confirming their distribution in expanded clusters or scattered throughout the chromosomes.... Wed, 12 Nov 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41209419/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251111002412&v=2.18.0.post22+67771e2 Host specificity is a critical feature of the survival and proliferation of parasites. In the context of interactions with the host, numerous mechanisms have been identified, particularly in parasitic helminths, that enable manipulation of the host immune system to enhance their own survival. The evolutionary history of these interactions often results in hosts becoming disease-tolerant or asymptomatic, even when burdened with a high number of worms, until a disruption in the host's immune... Mon, 10 Nov 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41182621/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251104002516&v=2.18.0.post22+67771e2 Understanding and identifying protein-ligand interactions is essential for elucidating fundamental biological processes and developing translational applications such as vaccine and drug targets. Yeast surface display (YSD) systems expressing genome-wide or combinatorial libraries in Saccharomyces cerevisiae are powerful tools to identify protein-ligand interactions in an unbiased fashion. In the following protocol, we couple the YSD system expressing a genome-wide library of the protozoan... Mon, 03 Nov 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41156739/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251030004755&v=2.18.0.post22+67771e2 Leishmaniasis is a vector-borne parasitic disease caused by Leishmania spp., transmitted to humans by phlebotomine sand flies. The development of Leishmania into infective metacyclic promastigotes occurs within the sand fly gut, where the bacterial microbiota plays a pivotal role in parasite development and transmission dynamics. This study aimed to characterize the gut bacterial composition of phlebotomine sand flies collected from both endemic (Lalla Aaziza) and non-endemic (Marrakech) regions... Wed, 29 Oct 2025 06:00:00 -0400