91丝瓜视频

The Feindel Brain and Mind Seminar Series will advance the vision of Dr. William Feindel (1918鈥�2014), Former Director of the Neuro (1972鈥�1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.

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Host: Jean-Baptiste Poline

Towards federated neuroscience research in the emerging era of data sovereignty

Abstract: Shared access to well-curated large, globally inclusive datasets is critical for the development, validation, and translation of novel biomarkers and prognostic tools in the clinic. Nonetheless, geographical separation and data governance policies often pose technical and privacy issues that complicate and constrain en masse integration and analysis of multicentric datasets. This talk will show progress in learning and validating brain biomarkers and prognostic models of age related neurodegenerative diseases with decentralized datasets. It will discuss the associated hurdles and make a case for investment in neuroinformatic infrastructure for managing studies with heterogeneous computational setups and governance policies. It will feature lightweight neuroinformatic tools - Nipoppy and Neurobagel, developed to address the needs of changing neuroscience research prompted by shift towards decentralized paradigms. The Nipoppy framework facilitates standardization of study-level data workflows across sites, allowing global researchers to share consistent, derived datasets that are often subject to less restrictive policy. The Neurobagel tools enable semantic harmonization, and privacy-aware data discovery crucial for mega-analyses and replication experiments. The talk will conclude with a federated analysis case-study performed in a multicentric ENIGMA-PD consortium, followed with a discussion on community building efforts to promote replicable, inclusive research at scale to improve our understanding of brain disorders and clinical outcomes.

Nikhil Bhagwat

Academic Associate, The Neuro, 91丝瓜视频

Nikhil is a computational neuroscientist with industry and academic research experience in neuroimaging and machine-learning. He's interested in development of robust biomarkers and machine-learning models for prognosis in neurodegenerative diseases. Currently he focus on development of neuroinformatic tools and implementation of reproducible computational workflows to assess and improve replication of imaging biomarkers and ML models. Concurrently, he also involved in open-science and data harmonization projects relating to curation of diverse, open datasets representative of global populations.

At present, he's working with聽Dr. Jean-Baptiste Poline聽in the聽ORIGAMI聽lab at 91丝瓜视频. He has completed his PhD thesis on prognostic applications for Alzheimer鈥檚 disease using MR imaging and machine-learning techniques under聽Dr. Mallar Chakravarty聽at the University of Toronto. Subsequently, he's worked as a researcher on a collaborative project between 91丝瓜视频 and UMass universities assessing reproducibility of computational pipelines estimating cortical surfaces measures. He then went on to work at the聽Allen Institute, where he developed segmentation techniques and network spread models for quantifying cellular pathologies of Alzheimer鈥檚 disease in high-resolution microscopy data.

Within the larger research community, he's involved in multiple open-science and sustainable-neuroimaging initiatives. He develops and teaches several 鈥渙pen鈥� workshops (e.g.聽MAIN聽and聽educational courses. I am also a current treasurer for the聽Sustainability & Environmental Action SIG聽within the聽Organization for Human Brain Mapping (OHBM)聽working on promoting sustainable research practices and conferencing.