Mahtab Tavasoli
Dr. Mahtab Tavasoli is an Assistant Professor at the Montreal Neurological Institute (The Neuro), 91丝瓜视频. She obtained her PhD from the University of Alberta and completed postdoctoral training at Harvard Medical School and Dalhousie University.
Dr. Tavasoli's research investigates how lipid metabolism governs neuronal function and vulnerability in neurodegenerative disease. She focuses on the role of phospholipid synthesis and membrane dynamics as key regulators of cellular homeostasis, integrating lipidomics, live-cell imaging, and metabolic profiling to define how disruptions in lipid balance drive pathogenesis in disorders such as Parkinson鈥檚 disease. Her work aims to uncover mechanistic links between lipid dysregulation and neurodegeneration and to identify lipid-targeted therapeutic strategies. In parallel, Dr. Tavasoli develops preclinical gene therapy approaches for rare genetic disorders of lipid metabolism.
听
1. Tavasoli, M. et al. Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism. Nat Commun 13, 1559 (2022).
2. Tavasoli, M., Lahire, S., Reid, T., Brodovsky, M. & McMaster, C.R. Genetic diseases of the Kennedy pathways for membrane synthesis. J Biol Chem 295, 17877-17886 (2020).
3. Klockner, C. et al. Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly. Brain 145, 1916-1923 (2022).
4. Tavasoli, M. et al. Neurodevelopmental disease-causing variants in choline kinase CHKA gene couple phosphatidylcholine synthesis to oxidative stress damage and disease etiology. J Biol Chem 302, 110983 (2026).