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UID:20260806T150249EDT-9331AiPwPv@132.216.98.100
DTSTAMP:20260806T190249Z
DESCRIPTION:Seminar Title:\n\nFluorescence microscopy: a minimum for maxima
 l spatio-temporal resolution\n\n \n\nAbstract:\n\nI will discuss MINFLUX\,
  a molecular localization and superresolution method that has reached Angs
 tröm localization precision and resolution of the size of a fluorescent mo
 lecule. MINFLUX and the related MINSTED concept are being established for 
 routine applications in cell and molecular biology\, and ultimately struct
 ural biology. Relying on much fewer fluorescence photons than the widely u
 sed camera-based localization methods\, these localization techniques are 
 poised to characterize dynamic processes of single proteins\, as demonstra
 ted by tracking the nanometer conformational changes of the motor proteins
  kinesin-1 [1\,2] and dynein in living cells [3]. MINFLUX has been demonst
 rated to measure intramolecular distances with Angström precision\, provid
 ing a precise and reliable alternative to FRET that also gives absolute 3D
  coordinates and hence vectorial 3D distances [4]. Harnessing confocal det
 ection\, MINFLUX provides nanometerrange resolution deeper down in layers 
 of cells and mildly scattering tissues [5]. Finally\, I will show an argua
 bly surprising ability of MINFLUX to separate individual identical fluorop
 hores without sequential ON/OFF switching or activation of fluorescence [6
 ]. Thus\, the simultaneous\, uninterrupted\, nanometer-scale tracking [7] 
 and imaging of multiple\, identical (same-color) fluorophores becomes poss
 ible for the first time. This novel superresolution principle should allow
  MINFLUX to reveal the conformational changes of individual biomolecules i
 n their native environment.\n\n \n\nBio:\n\nStefan Hell is a director at b
 oth the Max Planck Institute for Multidisciplinary Sciences in Göttingen a
 nd the Max Planck Institute for Medical Research in Heidelberg\, Germany.
 \n\nHell is credited with having conceived\, validated and applied the fir
 st viable concept for overcoming Abbe’s diffraction-limited resolution bar
 rier in a light-focusing fluorescence microscope. For this accomplishment 
 he has received numerous awards\, including the 2014 Kavli Prize in Nanosc
 ience and the Nobel Prize in Chemistry.\n\nStefan Hell received his doctor
 ate (1990) in physics from the University of Heidelberg. From 1991 to 1993
  he worked at the European Molecular Biology Laboratory\, followed by stay
 s as a senior researcher at the University of Turku\, Finland\, between 19
 93 and 1996\, and as a visiting scientist at the University of Oxford\, En
 gland\, in 1994. In 1997 he was appointed to the MPI for Biophysical Chemi
 stry (now MPI for Multidisciplinary Sciences) in Göttingen as a group lead
 er\, and was promoted to director in 2002.\n
DTSTART:20260901T170000Z
DTEND:20260901T183000Z
LOCATION:OM 112\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\,
  801 rue Sherbrooke Ouest
SUMMARY:91Ë¿¹ÏÊÓƵ Chemical Society Seminar Series- (JT Donald Lecture)\, Stefa
 n W. Hell
URL:/oss/channels/event/mcgill-chemical-society-semina
 r-series-jt-donald-lecture-stefan-w-hell-373697
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