BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260310T013400EDT-0550vu58Ov@132.216.98.100 DTSTAMP:20260310T053400Z DESCRIPTION:The Feindel Brain and Mind Seminar Series will advance the visi on of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1972 –1984)\, to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology\, co gnitive neuroscience\, and neuroimaging.\n\nSpeakers will include scientis ts from across The Neuro\, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual fo rum for scientists and trainees to continue to foster interdisciplinary ex changes on the mechanisms\, diagnosis and treatment of brain and cognitive disorders.\n\n\nRegister for In-Person\n\nTo watch online\, click here\n \nHost: Marco Leyton\n\n\n \n\nDrug and Stress Effects on D2 and mGlu5 Rece ptors: The Transition to Addictions and Their Comorbid Disorders\n\nAbstra ct: Dopamine D2/3 and glutamate mGluR5 receptor systems are key regulators of reward learning\, stress responsivity\, and neuroplasticity\, and have been strongly implicated in substance use disorders (SUDs). However\, it remains unclear whether receptor alterations reflect pre-existing vulnerab ility or consequences of substance exposure. This lecture presents longitu dinal PET findings from a high-risk cohort studied at ages 18 and 25 using [¹⁸F]fallypride (D2/3) and [¹¹C]ABP688 (mGluR5)\, alongside clinical and substance use assessments. The work examines neurochemical changes occurri ng before and after the onset of SUD and other DSM-5 disorders\, and how t hese changes relate to substance use and stress. Results show that individ uals who later developed SUD had higher striatal D2/3 receptor availabilit y at age 18\, followed by marked declines by age 25\, with greater decreas es associated with increased alcohol use. In contrast\, mGluR5 declines we re observed across emerging DSM-5 disorders and were linked to drug exposu re and stress\, with stress effects amplified among individuals with great er increases in drug use. Together\, these longitudinal findings highlight developmental changes in dopamine and glutamate systems that help explain vulnerability\, neuroadaptation\, and the emergence of addiction and rela ted psychopathology.\n\nMaja Nikolic\n\nPhD Candidate\, McGil University\n \nMaja Nikolic is a PhD candidate in Neuroscience at 91˿Ƶ in the laboratory of Dr. Marco Leyton. Her research investigates how temperam ent\, early life adversity\, and mesocorticolimbic circuits interact acros s development to increase vulnerability to substance use disorders. She st udies addiction vulnerability using longitudinal PET and fMRI in a high-ri sk cohort\, focusing on dopamine D2/3 receptors ([18F]fallypride) and glut amate mGluR5 ([11C]ABP688) markers and their relationships with substance use\, stress\, and emerging psychopathology. In addition\, she conducts st ructured clinical interviews (SCID-5) to characterize psychiatric outcomes and integrates clinical and neuroimaging data to model trajectories of ri sk and resilience.\n DTSTART:20260223T180000Z DTEND:20260223T190000Z LOCATION:De Grandpré Communications Centre\, The Neuro SUMMARY:Feindel Brain and Mind Seminar Series: Drug and Stress Effects on D 2 and mGlu5 Receptors: The Transition to Addictions and Their Comorbid Dis orders URL:/neuro/channels/event/feindel-brain-and-mind-semin ar-series-drug-and-stress-effects-d2-and-mglu5-receptors-transition-371327 END:VEVENT END:VCALENDAR