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UID:20251220T005332EST-7704aU5KBi@132.216.98.100
DTSTAMP:20251220T055332Z
DESCRIPTION:The Neuro's Dorothy J. Killam Lecture was established in 2004 t
 o recognize women of influence in business\, science\, politics or the hum
 anities.\n\nSpeaker: Gina Turrigiano\, PhD\n	Joseph Levitan Chair\, Departm
 ent of Biology\, Brandeis University\, Waltham\, USA\n\nAbstract: Our brai
 ns must generate and maintain stable activity patterns over decades of lif
 e\, despite the dramatic changes in circuit connectivity and function indu
 ced by learning and experience-dependent plasticity. How do our brains ach
 eive this balance between opposing need for plasticity and stability? Over
  the past two decades\, we and others have uncovered a family of “homeosta
 tic” negative feedback mechanisms that are theorized to stabilize overall 
 brain activity while allowing specific connections to be reconfigured by e
 xperience. Here I discuss recent work in which we demonstrate that individ
 ual neocortical neurons in freely behaving animals indeed have a homeostat
 ic activity set-point\, to which they return in the face of perturbations.
  Intriguingly\, this firing rate homeostasis is gated by sleep/wake states
  in a manner that depends on the direction of homeostatic regulation: upwa
 rd-firing rate homeostasis occurs selectively during periods of active wak
 e\, while downward-firing rate homeostasis occurs selectively during perio
 ds of sleep\, suggesting that an important function of sleep is to tempora
 lly segregate bidirectional plasticity. Finally\, we show that firing rate
  homeostasis is compromised in an animal model of autism spectrum disorder
 . Together our findings suggest that loss of homeostatic plasticity in som
 e neurological disorders may render central circuits unable to compensate 
 for the normal perturbations induced by development and learning.\n\nRegis
 tration is available here.\n
DTSTART:20220217T210000Z
DTEND:20220217T220000Z
LOCATION:CA\, QC\, Montreal
SUMMARY:Dorothy J Killam Lecture - Keeping your Brain in Balance: the Ups a
 nd Downs of Homeostatic Plasticity (virtual)
URL:/neuro/channels/event/dorothy-j-killam-lecture-kee
 ping-your-brain-balance-ups-and-downs-homeostatic-plasticity-virtual-33468
 6
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