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UID:20251219T031955EST-56489e63S3@132.216.98.100
DTSTAMP:20251219T081955Z
DESCRIPTION:Speaker: David Dupret\, Ph.D.\n\n\n	\n		\n			\n				Professor of Neuroscie
 nce\, MRC Investigator\, Brain Network Dynamics Unit\, University of Oxfor
 d\, UK\n\n				Registration: available now on Eventbrite\n\n				Livestreaming via V
 imeo: Vimeo\n\n				Abstract: The concerted activity of hippocampal neurons sup
 ports information processing with relevance to memory. Continually assimil
 ating new information without corrupting previously acquired ones may be a
  critical operation performed by the hippocampus\, allowing this network t
 o nest multiple\, co-existing memories. However\, memories typically inter
 act. Notably\, prior knowledge can proactively influence ongoing learning\
 , and new information can retroactively modify pre-existing memories. In t
 his talk\, I will first present recent work investigating some of the neur
 onal operations that enable to incorporate new experiences in the hippocam
 pus network\, segregating them as discrete traces while enabling their int
 eraction. By embedding coactive neurons in mathematical graphs\, this work
  describes that mnemonic information spans multiple operational axes in th
 e mouse hippocampus network. High activity principal cells form the core o
 f each memory along a first axis\, segregating spatial contexts and novelt
 y. Low activity cells join coactivity motifs across behavioural events and
  enable their crosstalk along two other axes. I will then discuss how disc
 rete\, co-existing memories can be stitched together beyond direct experie
 nce. I will present recent work that leverages from a parallel cross-speci
 es approach to characterize the neural computations underlying inferential
  reasoning in humans and mice. In so doing\, I will discuss the idea that 
 the mammalian hippocampus prospectively represents learned associations ne
 cessary for inference at the time of choice\, to then “join the dots” betw
 een memory items that were not directly experienced together but are logic
 ally related. Altogether\, these findings will notably support the idea th
 at short-timescale coactivity amongst hippocampal neurons act as a primary
  code that supports memory.\n\n				\n				The Killam Seminar Series at The Neuro\n
 \n				Supported by the generosity of the Killam Trusts\, The Neuro’s Killam Se
 minar series hosts outstanding guest speakers whose research is of interes
 t to the scientific community at The Neuro and 91˿����Ƶ.\n\n				\n				How
  to participate via Zoom:\n\n				1. You can either join a meeting via the invi
 te link or the Meeting ID #.\n\n				2. If you click the link it will automatic
 ally bring you to the meeting. If you do not have the link and only the me
 eting ID go to the Zoom application and click “Join a meeting” where it wi
 ll prompt you to input your name and the Meeting ID #.\n\n				3. Use the toolb
 ar at the bottom of your screen to mute/unmute yourself and to enable/disa
 ble your video.\n			\n		\n	\n\n
DTSTART:20210608T180000Z
DTEND:20210608T190000Z
SUMMARY:Killam Seminar Series: 'Joining-the-dots' in Memory
URL:/neuro/channels/event/killam-seminar-series-joinin
 g-dots-memory-330990
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