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UID:20251218T181430EST-6162fT3cMN@132.216.98.100
DTSTAMP:20251218T231430Z
DESCRIPTION:Speaker: Maja Jagodic\, PhD\n\nProfessor in Neuroinflammation\,
  Department of Clinical Neuroscience\, Center for Molecular Medicine\, Kar
 olinska Institutet\, Stockholm\, Sweden\n\nRegistration: available now on 
 Eventbrite\n\nLivestreaming via Vimeo: Vimeo\n\nAbstract: Multiple Scleros
 is (MS) is a leading cause of progressive disability in young adults. Alth
 ough the cause remains unknown\, vast epidemiological data establish MS as
  a complex disease influenced by genetic and environmental factors. Epigen
 etic mechanisms\, such as DNA methylation\, histone posttranslational modi
 fications and non-coding RNAs\, orchestrate activity of the genome in resp
 onse to environmental cues and may provide understanding of molecular mech
 anisms underpinning disease development and progression. To understand MS 
 pathogenesis\, we are measuring DNA methylation patterns and transcription
  in discrete cell types from unique clinical cohorts in combination with f
 unctional studies in experimental models in vitro and in vivo. One of the 
 main challenges with studying diseases such as MS is the limited access to
  the target tissue - the brain. Recent technical and analytical advances i
 n methods to survey epigenetic modifications genome-wide and from them inf
 er genome activity\, opened up possibilities to study brain tissue and mec
 hanisms that underlie neurodegeneration in MS patients.\n\n\nThe Killam Se
 minar Series at The Neuro\n\nSupported by the generosity of the Killam Tru
 sts\, The Neuro’s Killam Seminar series hosts outstanding guest speakers w
 hose research is of interest to the scientific community at The Neuro and 
 91˿����Ƶ.\n\n\nHow to participate via Zoom:\n\n1. You can either 
 join a meeting via the invite link or the Meeting ID #.\n\n2. If you click
  the link it will automatically bring you to the meeting. If you do not ha
 ve the link and only the meeting ID go to the Zoom application and click “
 Join a meeting” where it will prompt you to input your name and the Meetin
 g ID #.\n\n3. Use the toolbar at the bottom of your screen to mute/unmute 
 yourself and to enable/disable your video.\n
DTSTART:20210511T200000Z
DTEND:20210511T210000Z
SUMMARY:Killam Seminar Series: Uncovering Pathogenesis of Multiple Sclerosi
 s Using Applied Epigenomics
URL:/neuro/channels/event/killam-seminar-series-uncove
 ring-pathogenesis-multiple-sclerosis-using-applied-epigenomics-330715
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