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UID:20251219T031136EST-5710vuFDrA@132.216.98.100
DTSTAMP:20251219T081136Z
DESCRIPTION:Speaker: Leif Østergaard\, MSc\, MD\, PhD\, DMSc\n\nDirector\, 
 Center of Functionally Integrative Neuroscience\, and Lundbeck Foundation 
 and Clinical Professor\, Department of Clinical Medicine\, Aarhus Universi
 ty\, Denmark\n\nRegistration: available now on Eventbrite\n\nLivestreaming
  via Vimeo: Vimeo\n\nAbstract: What is the role of capillaries in neurovas
 cular coupling? Does capillary dysfunction contribute to the pathophysiolo
 gy of cerebrovascular diseases and Alzheimer’s Disease? The Killam Seminar
  discusses how capillary transit-time heterogeneity (CTH) affects the tran
 sport of oxygen from blood into tissue – and how disease-related capillary
  changes may limit tissue oxygenation in aging and disease. In brain tissu
 e\, oxygen availability is traditionally inferred from the regional cerebr
 al blood flow (CBF). Tissue oxygen uptake\, however\, is limited by blood’
 s transit time – the time available for blood-tissue diffusion exchange be
 fore blood returns to the heart. Therefore\, as CBF increases to meet meta
 bolic demands during brain work\, oxygen extraction becomes less efficient
  in parallel. The seminar describes how higher CBF and homogenization of c
 apillary flow patterns (lower CTH)\, combined\, affect oxygen availability
  in brain tissue and the blood oxygen level dependent (BOLD) contrast util
 ized by functional MRI. Theoretically\, age-\, risk factor-\, and disease-
 related deterioration of capillary function can cause severe tissue hypoxi
 a\, even in the absence of any blood flow-limiting conditions per se. The 
 Seminar will summarize recent observations of capillary flow patterns by M
 RI in human brain and by optical imaging techniques in rodents\, and discu
 sse their significance in the context of aging\, stroke and dementia.\n\n
 \nThe Killam Seminar Series at The Neuro\n\nSupported by the generosity of
  the Killam Trusts\, The Neuro’s Killam Seminar series hosts outstanding g
 uest speakers whose research is of interest to the scientific community at
  The Neuro and 91˿����Ƶ.\n\n\nHow to participate via Zoom:\n\n1. 
 You can either join a meeting via the invite link or the Meeting ID #.\n\n
 2. If you click the link it will automatically bring you to the meeting. I
 f you do not have the link and only the meeting ID go to the Zoom applicat
 ion and click “Join a meeting” where it will prompt you to input your name
  and the Meeting ID #.\n\n3. Use the toolbar at the bottom of your screen 
 to mute/unmute yourself and to enable/disable your video.\n
DTSTART:20210413T200000Z
DTEND:20210413T210000Z
SUMMARY:Killam Seminar Series: Capillaries\, BOLD\, and Brain Disorders
URL:/neuro/channels/event/killam-seminar-series-capill
 aries-bold-and-brain-disorders-330179
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