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UID:20251228T070526EST-5476SgvU5f@132.216.98.100
DTSTAMP:20251228T120526Z
DESCRIPTION:Speaker: William D. Rooney\, PhD\n\nProfessor and Director\, Ad
 vanced Imaging Research Center\, Oregon Health & Science University\, Port
 land\, USA\n\nRegistration: available now on Eventbrite\n\nLivestreaming v
 ia Vimeo: Vimeo\n\nAbstract: The normally functioning blood-brain barrier 
 (BBB) regulates the transfer of material between blood and brain. BBB dysf
 unction has long been recognized in multiple sclerosis (MS)\, and there is
  considerable interest in quantifying functional aspects of brain blood ve
 ssels and their role in disease progression. Parenchymal water content and
  its association with volume regulation is important for proper brain func
 tion\, and is one of the key roles of the BBB. There is convincing evidenc
 e that the astrocyte is critical in establishing and maintaining a functio
 nal BBB and providing metabolic support to neurons. Increasing evidence su
 ggests that functional interactions between endothelia\, pericytes\, astro
 cytes\, and neurons\, collectively known as the neurovascular unit\, contr
 ibute to brain water regulation\, capillary blood volume and flow\, BBB pe
 rmeability\, and are responsive to metabolic demands. Increasing evidence 
 suggests altered metabolism in MS brain which may contribute to reduced ne
 uro-repair and increased neurodegeneration. Metabolically relevant biomark
 ers may provide sensitive readouts of brain tissue at risk of degeneration
 \, and magnetic resonance offers substantial promise in this regard. Dynam
 ic contrast enhanced MRI combined with appropriate pharmacokinetic modelin
 g allows quantification of distinct features of BBB including permeabiliti
 es to contrast agent and water\, with rate constants that differ by six or
 ders of magnitude. Mapping of these rate constants provides unique biologi
 cal aspects of brain vasculature relevant to MS.\n\n\nThe Killam Seminar S
 eries at The Neuro\n\nSupported by the generosity of the Killam Trusts\, T
 he Neuro’s Killam Seminar series hosts outstanding guest speakers whose re
 search is of interest to the scientific community at The Neuro and 91˿����Ƶ 
 University.\n\n\nHow to participate via Zoom:\n\n1. You can either join a 
 meeting via the invite link or the Meeting ID #.\n\n2. If you click the li
 nk it will automatically bring you to the meeting. If you do not have the 
 link and only the meeting ID go to the Zoom application and click “Join a 
 meeting” where it will prompt you to input your name and the Meeting ID #.
 \n\n3. Use the toolbar at the bottom of your screen to mute/unmute yoursel
 f and to enable/disable your video.\n
DTSTART:20210406T200000Z
DTEND:20210406T210000Z
SUMMARY:Killam Seminar Series: Magnetic Resonance Measures of Brain Blood V
 essels\, Metabolic Activity\, and Pathology in Multiple Sclerosis
URL:/neuro/channels/event/killam-seminar-series-magnet
 ic-resonance-measures-brain-blood-vessels-metabolic-activity-and-329990
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