BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260303T180654EST-11260Honhu@132.216.98.100 DTSTAMP:20260303T230654Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nC all for Abstracts\n\nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilep sy Day 2026. \n\nWe encourage abstracts at any stage of a project’s develo pment—from literature reviews and research questions to pilot data and ong oing studies.\n\nSubmission deadline: March 23\, 2026\n\nSubmit Your Abstr act Here\n\nSelected abstracts will be featured in the poster session\, an d five outstanding posters will be invited to give a short oral presentati on during the program.\n\n\n\n \n Programme\n Speakers\n The Pierre Gloor Lect ure\n Location\n Sponsors\n Scientific Committee\n \n\n \n Thursday\, May 28\, 2 026\n\n Preliminary Program \n\n \n \n \n 9:15\n \n Arrival & Registration\n \n \n \n 9:30\n \n Lab Tours\n\n Neuroimaging\, EEG/FMRI\, MEG\,\n \n \n \n 10:45\n \n Wel come and Introduction\n\n Boris Bernhardt\, PhD\n Associate Professor of Neu rology and Neurosurgery\n Epilepsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n Irene Wang\, PhD\n Research Director and Staff Scient ist\n Cleveland Clinic Epilepsy Center\n\n Networks\n\n Seok-Jun Hong\, PhD\n Associate Professor of Biomedical Engineering Department\, SKKU\n Sungkyunk wan University - 91˿Ƶ\n\n Surgical Approaches and Innovations in FCD\n\n Roy William Dudley\, FRCSC\n Assistant Professor\, Department of Pediatric Surgery\, Department of Neurology & Neurosurgery\n Montreal Child ren's Hospital\n\n Alexander G. Weil\, FRCSC\, FACS\n Associate Professor\, Neurosurgeon\, Researcher\, Director\n University of Montreal - Sainte-Just ine Hospital Research Centre\n\n Jeffery Allan Hall\, FRCSC\n Assistant Prof essor of Neurology and Neurosurgery\n Epilepsy Programme\, Neurosurgery Cli nic\, Brain Tumour Clinic\n\n Sami Obaid\, MD\, PhD\, FRCSC Clinical Assist ant Professor\, Neurosurgeon Department of Surgery\, Faculty of Medicine C entre hospitaliser de l'Université de Montréal\n \n \n \n 1:00\n \n Lunch and Po ster Session\n \n \n \n 2:00\n \n Oral Presentations\n \n \n \n 3:00\n \n Coffee Break \n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research director and Grou p Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n \n Discussion Panel\n\n Samantha Audrain\, PhD \n\n Alexander Barnett\, PhD \n\n Stéphanie  Baulac\, PhD \n\n Andrea Bernasconi\, MD  \n\n Boris Bernhardt\, PhD \n\n Ne da Ladbon-Bernasconi\, PhD  \n\n Sara Lariviere\, PhD  \n\n Raluca Pana\, MD \, FRCP\, CSCN \n\n Myriam Srour\, MDCM\, PhD \n \n \n \n 5:00\n \n Cocktail Rece ption (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Keynotes:\n\n Irene Wang | Improv ing Epilepsy Surgery Planning Using MR Fingerprinting\n\n Dr. Irene Wang is the Research Director and Full Staff at the Cleveland Clinic Epilepsy Cen ter and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her research advances surgical treatments for MRI-ne gative epilepsy patients through innovative imaging and neurophysiology te chniques. As a trained biomedical engineer with a strong foundation in cli nical neurophysiology and neuroimaging\, Dr. Wang has pioneered the integr ation of advanced imaging into clinical practice to enhance patient care. She has authored over 120 peer-reviewed papers and serves as Associate Edi tor for Epilepsia. Dr. Wang has received continuous support from the Natio nal Institute of Health and serves as a charter member of the NIH Imaging Technology for Neuroscience study section. Dr. Wang also chairs the MRI Da ta Task Force of the ILAE Big Data Commission and serves on the Imaging Ta sk Force of the ILAE Diagnostic Methods Commission.\n \n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n This talk will focus on MR Fin gerprinting (MRF)\, a novel quantitative MRI technique that enables simult aneous acquisition of multiple tissue parameters within a single\, time-ef ficient acquisition\, providing a comprehensive multiparametric characteri zation of brain tissue properties. The talk will include clinical examples and studies demonstrating the added value of MRF for detection and subtyp e characterization of focal cortical dysplasia\, including cases with subt le or nonlesional findings on conventional MRI. The talk will further expl ore the potential of MRF-derived tissue metrics to inform in vivo epilepto genicity in more complex malformations of cortical development\, such as p eriventricular nodular heterotopia and polymicrogyria. Together\, these ex amples illustrate how MRF can enhance presurgical localization\, optimize SEEG implantation\, and improve prognostication for epilepsy surgery candi dates.\n\n  \n\n Stéphanie Baulac | Pierre Gloor Lecture\n\n Stéphanie Baulac is a Research Director at Inserm and Group Leader at the Paris Brain Inst itute (ICM) of the MOSAIC Team « Genetic Mosaicism in Epilepsy and Neurode velopmental Disorders » Her team implements a comprehensive translational approach spanning from the identification and characterization of somatic mutations in brain tissues obtained from patients undergoing epilepsy surg ery to in-depth functional analysis\, combining functional testing on pati ent-derived brain organoids\, and mouse models. \n \n Brain Mosaicism in Epi lepsies and Cortical Malformations\n Focal cortical dysplasia type II (FCDI I) is a cortical malformation causing refractory epilepsy\, resulting from developmental somatic mutations in mTOR pathway genes. To understand how these mutations create a mosaic pattern of affected cells and lead to cort ical dyslamination\, we performed comprehensive single-nucleus analyses of surgical samples from genetically-characterized FCDII patients. By combin ing genotyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affect glutamatergic neurons and astrocytes\ , creating distinct transcriptional programs in both mutated and non-mutat ed cells. This mosaicism drives cell-type-specific dysregulation of synapt ic and neurodevelopmental pathways that likely contribute to epileptogenes is. Notably\, our analysis of cytomegalic cells uncovered pronounced alter ations in mitochondrial metabolism pathways and cellular senescence. We un cover a signature associated with cellular senescence in abnormal FCDII ce lls and further provide evidence in preclinical FCDII mouse models that se nolytic agents could offer a novel therapeutic strategy for this disorder. \n\n  \n\n Seok-Jun Hong\n\n - Seok-Jun Hong\, PhD is an associate professor in the Department of Biomedical Engineering\, and Brain Science and Engin eering at Sungkyunkwan University (SKKU) and also affiliated with the Cent er for Neuroscience Imaging Research\, IBS in S. Korea. Before joining to SKKU\, he was a postdoctoral research fellow in Child Mind Institute at Ne w York\, working with Drs. Michael Milham and Adriana Di Martino\, and bef ore that\, in MNI with Dr. Boris Bernhardt. Dr. Hong’s previous research h as focused on advanced in-vivo multimodal magnetic resonance imaging of ty pical and atypical brain development (epilepsy and autism)\, especially ta rgeting a large-scale brain network organization. Building upon expertise in computer science\, statistics and neuroinformatics\, he has developed o riginal approaches to quantitatively describe connectome principles and it s developmental process in the human brain. These days\, his interest is h ow to inform biological inductive biases learned from the human brain to b uild up large-scale biophysical neural network models.\n\n  \n\n Sami Obaïd | Surgical approaches and innovations in FCD\n\n - Dr. Sami Obaïd\, M.D.\, Ph.D.\, is a neurosurgeon specializing in epilepsy at the Centre hospital ier de l’Université de Montréal (CHUM) and a Clinical Assistant Professor in the Department of Surgery at the Université de Montréal. He is also a p rincipal investigator at the CHUM Research Centre (CRCHUM)\, where he lead s the ONSET lab. His surgical practice is dedicated to epilepsy surgery\, and in 2024\, he was awarded the prestigious FRQS Junior 1 Researcher stat us. He underwent specialized training\, including a fellowship in epilepsy surgery at Yale University and a Ph.D. in structural neuroimaging applied to focal epilepsy. Dr. Obaïd focuses his clinical and scientific activiti es on the identification\, selection\, presurgical evaluation\, operative and postoperative management of patients with drug-resistant epilepsy thro ugh innovative neuroimaging techniques. Recognized early for his contribut ions to research\, an asteroid was named in his honor: the minor planet Ob aïd (21712). He has also been named a Distinguished Citizen of Canada for his scientific achievements\, listed among the “Top 20 Under 20”\, and one of his articles was awarded Discovery of the Year 2022 at the CRCHUS. He recently had the honor of serving as a guest co-speaker alongside astronau t Chris Hadfield\, reflecting the reach of his work and his commitment to science communication. A few months ago\, he also signed the Golden Book o f the King of Morocco in recognition of his academic and scientific accomp lishments. At the ONSET laboratory\, Dr. Obaïd currently supervises 22 gra duate students and two research assistants\, actively contributing to the training of the next generation of neuroscientists.\n\n  \n\n Roy Dudley | A ssociate Professor\, 91˿Ƶ Health Centre\n\n - Roy Dudley MD\, PhD is a an Associate Professor at 91˿Ƶ and a Pediatric Neur osurgeon at the Montreal Children's Hospital and the Montreal Neurological Hospital. He did his undergraduate studies in Biology and Mathematics at Memorial University of Newfoundland\, and his PhD in Experimental Medicine at 91˿Ƶ and the MNI with the late George Karpati. He returned to Newfou ndland for Medical School and came back to the MNI for Neurosurgery reside ncy under the epilepsy surgery tutelage of Jeffery Hall and Andre Olivier. He then did his Pediatric Neurosurgery Fellowship at the University of Co lorado in Denver. Dr. Dudley specializes in epilepsy surgery and is an FRS Q-sponsored clinical investigator with research program focused on optimiz ing the presurgical evaluation of focal epilepsy patients using advanced n euroimaging and electrophysiology\, improving the intraoperative localizat ion of malformations of cortical development\, such as focal cortical dysp lasia\, and overcoming the limitation of spatial coverage with SEEG.\n\n No vel Methods in SEEG to Optimize Epileptogenic Zone Localization and Functi onal Mapping: Overcoming the Limitation of Spatial Coverage\n\n Surgical tr eatment of refractory focal epilepsy can be curative and should be conside red as early as possible\, particularly in children. In challenging (usual ly MRI-negative) cases\, an intracerebral investigation via stereo-EEG (SE EG) is often necessary to localize the epileptogenic zone (EZ). Despite ad vanced neuroimaging/electrophysiology techniques and robotic technology\, the outcome of SEEG has improved little in 70 years\, the main drawbacks b eing the often-ill-informed pre-implantation hypotheses and the sparse cov erage of the brain\, resulting in under-sampling or completely missing the EZ and/or its borders\, and suboptimal stimulation for functional mapping . Our ongoing research aims to overcome these drawbacks of SEEG by (1) imp roving the pre-implantation hypothesis using novel methods in magnetoencep halography (MEG)\, such as virtual electrodes\, (2) optimizing SEEG signal analysis via simultaneous MEG/SEEG\, and (3) refining SEEG-based function al mapping via novel analysis (i.e.\, video/SEEG correlates) of spontaneou s movements and optimizing the stimulation parameters used to illicit icta l versus normal responses.\n\n \n \n\n \n The Pierre Gloor Lecture\n\n The Pier re Gloor Lecture celebrates the life and legacy of Pierre Gloor (1923–2003 )\, who joined The Neuro (Montreal Neurological Institute-Hospital) in 195 2 as a fellow in electroencephalography and neurophysiology. He trained un der Wilder Penfield and Herbert Jasper and earned his PhD from 91˿Ƶ Univ ersity in 1957. Gloor collaborated closely with clinical and research team s at The Neuro in advancing the understanding and treatment of epilepsy\, gaining international recognition for his contributions to the field.\n\n B rain Mosaicism in Epilepsies and Cortical Malformations\n\n Speaker: Stépha nie Baulac\, PhD\n Research director and Group Leader\n Inserm and Paris Bra in Institute (ICM)\n\n Focal cortical dysplasia type II (FCDII) is a cortic al malformation causing refractory epilepsy\, resulting from developmental somatic mutations in mTOR pathway genes. To understand how these mutation s create a mosaic pattern of affected cells and lead to cortical dyslamina tion\, we performed comprehensive single-nucleus analyses of surgical samp les from genetically-characterized FCDII patients. By combining genotyping and transcriptomics at single-cell resolution\, we revealed that mutation s predominantly affect glutamatergic neurons and astrocytes\, creating dis tinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and neurode velopmental pathways that likely contribute to epileptogenesis. Notably\, our analysis of cytomegalic cells uncovered pronounced alterations in mito chondrial metabolism pathways and cellular senescence. We uncover a signat ure associated with cellular senescence in abnormal FCDII cells and furthe r provide evidence in preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic strategy for this disorder.\n\n  \n\n \n \n \n \n Location\n\n The Montreal Neurological Institute and Hospital is at 380 1 University Street\, north of Pine Avenue West\, on the 91˿Ƶ campus opposite the former Royal Victoria Hospital.\n\n Montreal is served by highway Routes 10\, 15\, 20 and 40\, and by Greyhound Bus\, Via Rail a nd the P-E-Trudeau airport. In the city\, bus and metro service is provide d by the Société de transport de Montréal (STM).\n\n Wheelchair access\n\n A wheelchair accessible entrance is on University Street north of the main entrance. Another wheelchair accessible entrance is in the loading area be hind the building: to enter the loading area\, turn into the driveway sout h of the main entrance. Please note\, there is no parking in the loading a rea.\n\n Parking\n\n Parking near the MNI is sometimes difficult. There are parking meters on University Street and a parking lot north of the main en trance. To enter the lot\, turn right into the driveway toward Molson Stad ium.\n\n Information about parking fees\n\n Taxi Stand\n\n There is a taxi st and on University Street across from the main entrance. You may call a cab from the free taxi phone in the main lobby near the Security Desk.\n\n Acc ess by Public Transportation (STM website)\n\n Bus\n\n There are four bus st ops within walking distance:\n\n \n Bus 144 stops at Pine Avenue and Univers ity Street\n Bus 356 stops at Sherbrooke Street and University Street (Nigh tbus)\n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 stops at Sherbrooke Street and University Street\n \n\n Metro\n\n Take the Metro Green Line to the 91˿Ƶ station. Walk north on University Street and cross Pin e Avenue. The main entrance is on the right\, past the flags.\n\n Jeanne Ti mmins Amphitheatre\n\n \n Enter the main lobby\, turn left\, and go down the hallway to the end.\n Turn right and go down the second hallway until you see another hallway on the left.\n This hallway leads to the Jeanne Timmins Foyer.\n On your right are the Jeanne Timmins Amphitheatre entrance doors. \n \n \n\n \n Sponsors \n\n \n \n\n \n Scientific Committee\n\n Sam Audrain\n\n Alex ander Barnett\n\n Boris Bernhardt\n\n Sara Larivière\n\n Raluca Pana\n\n Debbi e Rashcovsky\n\n Myriam Srour\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/medsimcentre/channels/event/neuro-epilepsy-day-20 26-epilepsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR