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Interview with Thomas Duchaine: a vaccine that fights COVID-19… and cancer!

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Published: 15 December 2025

D2R's funded-researcher Thomas Duchaine recently sat down with Radio-Canada to discuss emerging research suggesting that RNA vaccines developed for COVID-19 may also enhance the effectiveness of certain cancer treatments. 

A recent study by a group of American researchers working on personalized mRNA cancer vaccines found that COVID-19 vaccines can have beneficial effects for cancer patients undergoing immunotherapy. The researchers observed that COVID-19 vaccines broadly activate the immune system in mice. This led them to investigate whether a similar effect occurs in humans. 

Their findings suggest that this immune-stimulating effect does indeed translate to human patients. The COVID-19 mRNA vaccine appears to act as an “alarm,” awakening immune cells within a patient’s tumor. Among patients receiving immunotherapy, vaccination was associated with significantly improved survival outcomes. These results indicate that mRNA COVID-19 vaccines may enhance the immune response in certain cancers treated with immunotherapy, thereby improving the effectiveness of these treatments. 

This discovery adds to a growing body of promising research advancing cancer care and highlighting the potential of cancer vaccines as therapeutic tools. While immunotherapy itself marked a major breakthrough offering hope to many patients who previously had limited options, the continued development of cancer vaccines could open even more avenues for effective treatment. 

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