BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20251217T170804EST-4115NlGevI@132.216.98.100 DTSTAMP:20251217T220804Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegistration coming soon.\n\n\nCall for Abstracts\n \nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilepsy Day 2026. \n\nWe encourage abstracts at any stage of a project’s development—from literatu re reviews and research questions to pilot data and ongoing studies.\n\nSu bmission deadline: March 23\, 2026\n\nSubmit Your Abstract Here\n\nSelecte d abstracts will be featured in the poster session\, and five outstanding posters will be invited to give a short oral presentation during the progr am.\n\n\n\n \n Programme\n Speakers\n The Pierre Gloor Lecture\n Location\n Spon sors\n Scientific Committee\n \n\n \n Thursday\, May 28\, 2026\n\n Preliminary Program \n\n \n \n \n 9:15\n \n Arrival & Registration\n \n \n \n 9:30\n \n Lab Tours \n\n Neuroimaging\, EEG/FMRI\, MEG\,\n \n \n \n 10:45\n \n Welcome and Introducti on\n\n Boris Bernhardt\, PhD\n Associate Professor of Neurology and Neurosur gery\n Epilepsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n \n Irene Wang\, PhD\n Research Director and Staff Scientist\n Cleveland Clini c Epilepsy Center\n\n Networks\n\n Seok-Jun Hong\, PhD\n Associate Professor of Biomedical Engineering Department\, SKKU\n Sungkyunkwan University - McG ill University\n\n Surgical Perspectives\n\n Roy William Dudley\, FRCSC\n Ass istant Professor\, Department of Pediatric Surgery\, Department of Neurolo gy & Neurosurgery\n Montreal Children's Hospital\n\n Alexander G. Weil\, FRC SC\, FACS\n Associate Professor\, Neurosurgeon\, Researcher\, Director\n Uni versity of Montreal - Sainte-Justine Hospital Research Centre\n\n Jeffery A llan Hall\, FRCSC\n Assistant Professor of Neurology and Neurosurgery\n Epil epsy Programme\, Neurosurgery Clinic\, Brain Tumour Clinic\n \n \n \n 1:00\n \n Lunch and Poster Session\n \n \n \n 2:00\n \n Oral Presentations\n \n \n \n 3:00\n \n Coffee Break\n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Brain Mosaicism in Epi lepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research direc tor and Group Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n \n Discussion Panel\n\n Stéphanie Baulac\, PhD\n\n Boris Bernhardt\, PhD\n\n R aluca Pana\, MD\, FRCP\, CSCN\n\n Myriam Srour\, MDCM\, PhD\n\n Alexander Ba rnett\, PhD\n\n Samantha Audrain\, PhD\n\n Sara Lariviere\, PhD \n\n Andrea B ernasconi\, MD\n\n Neda Labdon-Bernasconi\, PhD\n \n \n \n 5:00\n \n Cocktail Rec eption (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Keynotes:\n\n Irene Wang\n\n Dr. Irene Wang is the Research Director and Full Staff at the Cleveland Clinic Epilepsy Center and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her research advances surgical treatmen ts for MRI-negative epilepsy patients through innovative imaging and neuro physiology techniques. As a trained biomedical engineer with a strong foun dation in clinical neurophysiology and neuroimaging\, Dr. Wang has pioneer ed the integration of advanced imaging into clinical practice to enhance p atient care. She has authored over 120 peer-reviewed papers and serves as Associate Editor for Epilepsia. Dr. Wang has received continuous support f rom the National Institute of Health and serves as a charter member of the NIH Imaging Technology for Neuroscience study section. Dr. Wang also chai rs the MRI Data Task Force of the ILAE Big Data Commission and serves on t he Imaging Task Force of the ILAE Diagnostic Methods Commission.\n \n Improv ing Epilepsy Surgery Planning Using MR Fingerprinting\n More details to com e...\n\n  \n\n Stéphanie Baulac | Pierre Gloor Lecture\n\n Stéphanie Baulac i s a Research Director at Inserm and Group Leader at the Paris Brain Instit ute (ICM) of the MOSAIC Team « Genetic Mosaicism in Epilepsy and Neurodeve lopmental Disorders » Her team implements a comprehensive translational ap proach spanning from the identification and characterization of somatic mu tations in brain tissues obtained from patients undergoing epilepsy surger y to in-depth functional analysis\, combining functional testing on patien t-derived brain organoids\, and mouse models. \n \n Brain Mosaicism in Epile psies and Cortical Malformations\n Focal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy\, resulting from d evelopmental somatic mutations in mTOR pathway genes. To understand how th ese mutations create a mosaic pattern of affected cells and lead to cortic al dyslamination\, we performed comprehensive single-nucleus analyses of s urgical samples from genetically-characterized FCDII patients. By combinin g genotyping and transcriptomics at single-cell resolution\, we revealed t hat mutations predominantly affect glutamatergic neurons and astrocytes\, creating distinct transcriptional programs in both mutated and non-mutated cells. This mosaicism drives cell-type-specific dysregulation of synaptic and neurodevelopmental pathways that likely contribute to epileptogenesis . Notably\, our analysis of cytomegalic cells uncovered pronounced alterat ions in mitochondrial metabolism pathways and cellular senescence. We unco ver a signature associated with cellular senescence in abnormal FCDII cell s and further provide evidence in preclinical FCDII mouse models that seno lytic agents could offer a novel therapeutic strategy for this disorder.\n \n  \n\n \n \n\n \n The Pierre Gloor Lecture\n\n The Pierre Gloor Lecture celebr ates the life and legacy of Pierre Gloor (1923–2003)\, who joined The Neur o (Montreal Neurological Institute-Hospital) in 1952 as a fellow in electr oencephalography and neurophysiology. He trained under Wilder Penfield and Herbert Jasper and earned his PhD from 91Ë¿¹ÏÊÓƵ in 1957. Gloor c ollaborated closely with clinical and research teams at The Neuro in advan cing the understanding and treatment of epilepsy\, gaining international r ecognition for his contributions to the field.\n\n Brain Mosaicism in Epile psies and Cortical Malformations\n\n Speaker: Stéphanie Baulac\, PhD\n Resea rch director and Group Leader\n Inserm and Paris Brain Institute (ICM)\n\n F ocal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy\, resulting from developmental somatic mutations in m TOR pathway genes. To understand how these mutations create a mosaic patte rn of affected cells and lead to cortical dyslamination\, we performed com prehensive single-nucleus analyses of surgical samples from genetically-ch aracterized FCDII patients. By combining genotyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affect glutamatergic neurons and astrocytes\, creating distinct transcriptional p rograms in both mutated and non-mutated cells. This mosaicism drives cell- type-specific dysregulation of synaptic and neurodevelopmental pathways th at likely contribute to epileptogenesis. Notably\, our analysis of cytomeg alic cells uncovered pronounced alterations in mitochondrial metabolism pa thways and cellular senescence. We uncover a signature associated with cel lular senescence in abnormal FCDII cells and further provide evidence in p reclinical FCDII mouse models that senolytic agents could offer a novel th erapeutic strategy for this disorder.\n\n  \n\n \n \n\n \n Location\n\n The Mont real Neurological Institute and Hospital is at 3801 University Street\, no rth of Pine Avenue West\, on the 91Ë¿¹ÏÊÓƵ campus opposite the for mer Royal Victoria Hospital.\n\n Montreal is served by highway Routes 10\, 15\, 20 and 40\, and by Greyhound Bus\, Via Rail and the P-E-Trudeau airpo rt. In the city\, bus and metro service is provided by the Société de tran sport de Montréal (STM).\n\n Wheelchair access\n\n A wheelchair accessible e ntrance is on University Street north of the main entrance. Another wheelc hair accessible entrance is in the loading area behind the building: to en ter the loading area\, turn into the driveway south of the main entrance. Please note\, there is no parking in the loading area.\n\n Parking\n\n Parki ng near the MNI is sometimes difficult. There are parking meters on Univer sity Street and a parking lot north of the main entrance. To enter the lot \, turn right into the driveway toward Molson Stadium.\n\n Information abou t parking fees\n\n Taxi Stand\n\n There is a taxi stand on University Street across from the main entrance. You may call a cab from the free taxi phon e in the main lobby near the Security Desk.\n\n Access by Public Transporta tion (STM website)\n\n Bus\n\n There are four bus stops within walking dista nce:\n\n \n Bus 144 stops at Pine Avenue and University Street\n Bus 356 stop s at Sherbrooke Street and University Street (Nightbus)\n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 stops at Sherbrooke Street and Un iversity Street\n \n\n Metro\n\n Take the Metro Green Line to the 91Ë¿¹ÏÊÓƵ stat ion. Walk north on University Street and cross Pine Avenue. The main entra nce is on the right\, past the flags.\n\n Jeanne Timmins Amphitheatre\n\n \n Enter the main lobby\, turn left\, and go down the hallway to the end.\n Tu rn right and go down the second hallway until you see another hallway on t he left.\n This hallway leads to the Jeanne Timmins Foyer.\n On your right a re the Jeanne Timmins Amphitheatre entrance doors.\n \n \n\n \n Sponsors \n \n \n \n Scientific Committee\n\n Sam Audrain\n\n Alexander Barnett\n\n Boris Bern hardt\n\n Sara Larivière\n\n Raluca Pana\n\n Debbie Rashcovsky\n\n Myriam Srou r\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/dementia/channels/event/neuro-epilepsy-day-2026-e pilepsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR