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UID:20260805T235558EDT-1168pfBIl7@132.216.98.100
DTSTAMP:20260806T035558Z
DESCRIPTION:The past two decades have witnessed a paradigm shift in our\nun
 derstanding of cellular protein folding. While the\nthree-dimensional stru
 ctures of functional proteins are determined\nby their amino acid sequence
 s\, as originally demonstrated by\nAnfinsen\, it has become clear that wit
 hin the crowded environment\nof cells many proteins depend on so-called mo
 lecular chaperones to\nreach their folded states efficiently and at a biol
 ogically\nrelevant time scale. Assistance of protein folding is provided b
 y\ndifferent types of chaperone which act to prevent misfolding and\naggre
 gation\, often in an ATP-dependent mechanism. In the cytosol\,\nnascent ch
 ain-binding chaperones\, including Trigger factor and\nHsp70\, stabilize e
 longating polypeptide chains on ribosomes in a\nnon-aggregated state. Fold
 ing is then achieved either on controlled\nchain release from these factor
 s or following polypeptide transfer\nto downstream chaperones\, such as th
 e cylindrical chaperonins GroEL\nand TRiC. The latter provide nano-compart
 ments for single protein\nmolecules to fold in isolation\, unimpaired by a
 ggregation.\nOnce folded\, many proteins continue to require chaperones to
 \nretain their functional states\, particularly under conditions of\ncell 
 stress. Failure of the chaperone machinery to maintain\nproteostasis\, i.e
 . the conformational integrity of the cellular\nproteome\, may facilitate 
 the manifestation of diseases in which\nproteins misfold and are deposited
  as aggregates\, such as\nParkinson’s and Huntington’s disease. A decline 
 in proteostasis\ncapacity occurs during aging\, presumably explaining why 
 age is the\nmajor risk factor of neurodegenerative diseases. Motivated by 
 the\ndesire to find a cure for these ailments\, researchers are now\nsearc
 hing for drugs that can activate the chaperone system\, thereby\ndelaying 
 the onset of aggregation diseases and prolonging the\nhealthy human lifesp
 an.\n
DTSTART:20110819T160000Z
DTEND:20110819T170000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Biochemistry Seminar - Dr. F. Ulrich Hartl
URL:/channels/event/biochemistry-seminar-dr-f-ulrich-h
 artl-176258
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