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UID:20260811T014245EDT-9511RJVAVr@132.216.98.100
DTSTAMP:20260811T054245Z
DESCRIPTION:Title: Emulating Target Trials to Study the Effect of Lung Tran
 splantation on Survival in Cystic Fibrosis.\n\nAbstract: Ruth is Professor
  of Biostatistics & Epidemiology at the London School of Hygiene & Tropica
 l Medicine (Medical Statistics Department and Centre for Statistical Metho
 dology). Her research focuses on the development and application of statis
 tical causal inference methods for answering questions about the effects o
 f treatments on health outcomes using observational data from patient regi
 stries and electronic health records. She is particularly focusing on appl
 ications in the area of cystic fibrosis. Ruth is funded by a UK Research a
 nd Innovation Future Leaders Fellowship.\n	Link to website: https://www.lsh
 tm.ac.uk/aboutus/people/keogh.ruth\n\nCystic fibrosis (CF) is a life-short
 ening conditioning affecting around 10\,500 people in the UK\, and lung tr
 ansplantation is an option for people with CF who have end-stage lung dise
 ase. Making decisions about transplant is difficult and there is a lack of
  information about its benefits\, as randomized trials in this area are in
 feasible. Therefore\, understanding the impact of transplant on survival r
 elies on observational data such as national transplant registers. I will 
 discuss the use of “target trials” to articulate different causal question
 s about the effects of transplantation and discuss how to emulate the targ
 et trials using observational longitudinal data on patient measures\, tran
 splant status\, and survival. Causal questions include what the effect is 
 of joining the transplant wait-list and what the effect of transplant is i
 n those who received one. I will present some preliminary results based on
  data from the UK Cystic Fibrosis Registry and discuss plans for enhancing
  this work by making use of additional data sources.\n\nVia Zoom: https://
 mcgill.zoom.us/j/85978187693?pwd=WWtJZUpnb0JXK3o5SStnOFcxK3FFUT09\n\nWeb s
 ite : www.mcgill.ca/epi-biostat-occh/news-events/seminars/biostatistics\n
DTSTART:20211117T203000Z
DTEND:20211117T213000Z
SUMMARY:Ruth Keogh\, DPhil (London School of Hygiene & Tropical Medicine)
URL:/channels/channels/event/ruth-keogh-dphil-london-s
 chool-hygiene-tropical-medicine-334661
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