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UID:20260807T065746EDT-4424kaanMu@132.216.98.100
DTSTAMP:20260807T105746Z
DESCRIPTION:                   X marks the spot\n\n  When:  May 15\, 2017 1
 2:00 to 13\;00Where:  MUHC Glen Site Room EM 13509Also available at Duff M
 edical Building Room 112\n\nLéon C.L.T. van Kempen\, PhD\n	Assistant Profes
 sor Department of\, Pathology\, 91Ë¿¹ÏÊÓƵ\, Montreal\, QC\n	Chief O
 perating Officer\, Molecular Pathology Center\,\n	Jewish General Hospital\n
 	Clinical Molecular Biologist\, Department of Pathology\, University Medica
 l Center Groningen\, The Netherlands\n\nGender is a main prognostic factor
  for different cancer types\, including melanoma\, but the underpinning mo
 lecular mechanism is poorly understood. A recent break-through was made wi
 th our discovery that the X-chromosome status is critical for the expressi
 on of a novel gonosomal melanoma tumor suppressor gene\, i.e. PR70 (Scienc
 e TM\, 2016).  In this lecture\, I will describe how expression of X-linke
 d genes can be deregulated in melanoma\, how loss of PR70 activity contrib
 utes to melanoma progression\, and novel approaches to identify and target
  PR70-regulated proteins as means to develop the prognostic biomarker valu
 e of PR70 into a predictive biomarker for novel treatment options that are
  not limited to melanoma.\n\nDr. Léon C. van Kempen studied molecular biol
 ogy and biochemistry at the Radboud University Nijmegen\, The Netherlands.
  As part of his PhD program\, he elected for a 1 year training in melanoma
  molecular biology at the Wistar Institute\, Philadelphia\, and obtained h
 is PhD cum laude in 2001. After a postdoctoral fellowship at the Universit
 y of California in San Francisco focused on the of the microenvironment in
  cancer\, he returned to the department of Pathology at the University Med
 ical and was appointed associate professor in 2008 with research topics in
  melanoma\, vulvar carcinoma and head and neck cancers.  In 2010\, he was 
 recruited to 91Ë¿¹ÏÊÓƵ’s department of Pathology to co-develop a research pro
 gram in melanoma and help build the Molecular Pathology Center (MPC) at th
 e Jewish General Hospital.  He is the MPC’s chief operating officer since 
 its opening in 2013. In 2017\, Dr. van Kempen was appointed assistant prof
 essor at 91Ë¿¹ÏÊÓƵ’s department of Pathology\, and also holds a position as c
 linical molecular biologist in pathology at the University Medical Center 
 Groningen\, The Netherlands.\n\n \n\n \n
DTSTART:20170515T160000Z
DTEND:20170515T170000Z
LOCATION:CA\, MUHC Glen Room EM 13509\, 1001 Decarie Blvd\, Montreal\, QC\,
  CA
SUMMARY:Pathology Scientific Lecture Series-X marks the spot by Dr. Léon C.
 L.T. van Kempen\,
URL:/channels/event/pathology-scientific-lecture-serie
 s-2016-2017-267993
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