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DTSTAMP:20260730T030722Z
DESCRIPTION:Estimating the Impact of Cluster-Based Interventions: the SEARC
 H trial and HIV prevention in East Africa.\n\n \n\nDr. Laura Balzer is a P
 ost-Doctoral Fellow in the Department of Biostatistics at the Harvard T.H.
  Chan School of Public Health. She earned her PhD in Biostatistics from th
 e University of California\, Berkeley under the guidance of Drs. Maya Pete
 rsen and Mark van der Laan. Her research is on the development of optimal 
 designs and estimators for causal effects with highly dependent data. Appl
 ications of this work include impact evaluation for HIV prevention and tre
 atment strategies and understanding the neighborhood determinants of healt
 h. Laura is also passionate about teaching more advanced causal and statis
 tical methods to applied audiences. Jointly with Dr. Maya Petersen\, she w
 as awarded the 2014 ASA’s Causality in Statistics Education Award. (More i
 nfo: www.works.bepress.com/laura_balzer) \n\nEvaluation of cluster-based i
 nterventions presents significant methodological challenges. In this talk\
 , we describe the design and analysis of the SEARCH trial\, an ongoing com
 munity randomized trial to evaluate the impact of early HIV diagnosis and 
 immediate treatment with streamlined care in rural Uganda and Kenya. We fo
 cus on 3 choices to optimize the design and analysis: pair-matching over c
 omplete randomization\, targeting the sample effect instead of a populatio
 n average parameter\, and data-adaptive adjustment through a pre-specified
  targeted maximum likelihood estimator (TMLE). These choices are compared 
 theoretically and with finite sample simulations. We demonstrate each choi
 ce improves efficiency relative to standard practice\, while maintaining n
 ominal confidence interval coverage. We conclude with practical implicatio
 ns and some ongoing challenges.\n
DTSTART:20161018T193000Z
DTEND:20161018T203000Z
LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue
  des Pins Ouest
SUMMARY:Laura B. Balzer\, Harvard T.H. Chan School of Public Health
URL:/channels/event/laura-b-balzer-harvard-th-chan-sch
 ool-public-health-263290
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