BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260314T221209EDT-3304jEVtjI@132.216.98.100
DTSTAMP:20260315T021209Z
DESCRIPTION:SEMINAR: Cell biological mechanisms of Amyotrophic Lateral Scle
 rosis\n\nDr. Christine Vande Velde\n\nUniversity of Montreal\n\nDepartment
  of Neuroscience\n\n'Amyotrophic lateral sclerosis (ALS) is a fatal neurod
 egenerative disease characterized by the selective loss of motor neurons. 
 Efforts to design effective therapies are crippled by our lack of understa
 nding the molecular lesions and aberrant processes that lead to disease pa
 thogenesis. While several new players in ALS pathogenesis have recently em
 erged\, RNA binding proteins\, such as TDP-43 and hnRNP A1\, have become a
  primary focus. However\, little is understood about how these proteins in
 teract and/or coordinate RNA processing and metabolism. RBPs such as TDP-4
 3 and hnRNP A1 are both mutated in familial ALS cases and mislocalized int
 o cytoplasmic aggregates in the motor neurons of affected patients. In the
  case of TDP-43\, cytoplasmic inclusions are accompanied by a depletion of
  nuclear TDP-43. It is our hypothesis that mislocalisation of TDP-43 disru
 pts physiological functions within the nucleus. We will examine the downst
 ream consequences of nuclear TDP-43 depletion of various cell biological m
 echanisms.'\n\nwww.mcgill.ca/anatomy/seminars\n\nSEMINAR POSTER\n
DTSTART:20170222T163000Z
DTEND:20170222T173000Z
LOCATION:Strathcona Anatomy and Dentistry Building\, CA\, QC\, Montreal\, H
 3A 0C7\, 3640 rue University
SUMMARY:Seminar - Dr. Christine Vande Velde (UdeM) - 'Cell biological mecha
 nisms of Amyotrophic Lateral Sclerosis'
URL:/anatomy/channels/event/seminar-dr-christine-vande
 -velde-udem-cell-biological-mechanisms-amyotrophic-lateral-sclerosis-26541
 9
END:VEVENT
END:VCALENDAR